The English pair won the top two singles matches on the 18th hole to finish with four points apiece for the week, Rhodes sensationally coming back from four down after seven holes to defeat Kelly Xu.
The only player to outscore Rhodes and Fullbrook was world number three Farah O’Keefe, who became only the fourth player in Curtis Cup history – after Stacy Lewis, Bronte Law and Kristin Gillman - to end the match with a perfect five wins from five.
O’Keefe’s singles match was a microcosm of the final day. She was two down through 12 holes against Charlotte Naughton, but O’Keefe fought back to win 2&1, her individual success fittingly guaranteeing victory for the USA.
"Obviously we're disappointed," said Matthew, who was bidding to achieve a fourth team triumph as Captain after Solheim Cup success with Europe in 2019 and 2021 and Curtis Cup glory in 2024 with GB&I. "You're always disappointed when you lose. We came here with high hopes wanting to retain the cup that we won at Sunningdale two years ago. They fought their hardest. I'm very proud of them. They did their best. Each and every one of them battled out there in every single match, and that's all you can do."
The next Curtis Cup will take place in 2028 at Royal Dornoch in the Scottish Highlands, with the USA now leading the overall series 32-9-3.
Rhodes and Fullbrook sign off in style
It was no surprise to see visiting captain Matthew send out Rhodes and Fullbrook at the top of the order on Sunday, given the duo had combined for three of GB&I’s five victories across the first two days.
Rhodes got off to a dreadful start against Xu, who missed her graduation at Stanford University to play in this match and was given a special ceremony on the 10th tee earlier in the day.
GB&I’s highest-ranked player was four down through five and remained in that position after seven, only to then come charging back with wins at the 8th, 10th, 11th, 13th and 14th.
Xu refused to give in and showed her class with wonderful approaches to the 17th and 18th holes, but she could not convert her two birdie chances and Rhodes sealed a one up victory courtesy of a clutch 12-footer for par at the last.
As Rhodes completed her post-match interviews behind the final green, Fullbrook triumphed by the same margin thanks to a stunning approach to 18 that prompted Avery Weed to concede the birdie putt.
Americans turn the tide
Yet there was heartbreak for GB&I in match three, as Nellie Ong suffered the opposite experience to Rhodes. Four up through 11 against Jasmine Koo, Ong was beaten on the 18th as the USA suddenly started to gain telling advantages in a host of matches that had been delicately poised.